The Issue: 

To ensure a plentiful and safe food supply and the control human and animal pests , the EPA is charged under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) with registering pesticides in the U.S. and ensuring that their use poses limited risks to human health and the environment.   

The Solution:  

To support the registration and use of pesticides in the U.S., agrochemical companies are required to submit numerous studies examining the toxicity of the pesticides to mammals and other non-target species, along with studies examining the fate (movement, degradation, metabolism) of pesticides in the environment.  As these studies form the basis for EPA’s regulatory decisions, they must be independently evaluated to ensure that they are scientifically sound and conducted in accordance with current regulatory standards.  CSS scientists provide EPA and independent and unbiased review of this data.

CSS Innovations and Contributions: 

For more than 35 years covering multiple concurrent contracts, CSS scientists have supported EPA/OPP in the review and evaluation of the wide array of studies supporting pesticide registrations.   To support human health risk assessments, our scientists review and evaluate studies pertaining to pesticide toxicity in model mammalian species in order to estimate potential toxicity to humans.  These studies include both short- and long-term studies examining general toxicity, potential carcinogenicity, and reproductive effects.  We evaluate studies examining potential pesticide residues in food and livestock commodities that serve as the basis of establishing allowable tolerances and estimating dietary exposure. To support environmental risk assessments, we also review studies examining toxicity to non-target plant and animal species, as well as, the movement and fate of pesticides in the environment.   For all these reviews, our scientist prepare concise reports evaluating the study’s procedures, results and conclusions, and its adequacy in fulfilling regulatory requirements.

Key Technical Services

  • Evaluation of pesticide residues in food/feed crops and livestock
  • Evaluation of mammalian toxicity data for pesticides
  • Determination of critical end-points, NOAELs and LOAELs (no- and lowest-observed adverse effect level), RfDs and RfCs (acceptable reference doses and concentrations), and cancer values
  • Risk assessment and Weight of Evidence (WoE) analyses.
  • Evaluation of chemical toxicity to non-target species
  • Movement, metabolism, and degradation of pesticides in the environment
  • Evaluation of regulatory compliance and quality assurance

Additional Projects

Mobilizing Onsite at National Special Security Events

CSS operates and maintains EPA mobile analytical units that travel to support multi-agency security efforts during high profile events that draw large crowds. 

Pacific Ecological Services Division Project (PESD)

Since 1996 CSS has conducted field and lab-based research in support of the Pacific Ecological Services Division Project

Audit and Inspection Support for the National Institute of Environmental Health Sciences (NIEHS)

For more than 35 years, CSS has provided quality control assessment support to the National Toxicology Program (NTP) on studies relating to the toxicological effects of chemicals in the environment.

Safety, Health, & Environmental

We provide our clients with tools to protect their workforce, the public, and the environment.

Environmental Resource Assessment & Management

We apply science to address challenges affecting the nation’s natural resources.

IT Services

Our IT solutions meet clients’ evolving needs.

Emergency Preparedness & Response

We help our clients prepare for and protect the health and environment of communities after disasters and hazmat releases.

Facilities Operations & Maintenance

We understand your facility support needs and deliver customized solutions.

Satellite Data Applications

Helping create a more environmentally sustainable, weather-ready, and secure nation through application of earth observation data  

Earth & Space Science Support & Operations

We deliver scientific support to advance our clients’ research goals.

Get in touch

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