News & Awards

Project Supported by CSS Scientists in Latest Issue of "Scientific American"

March 21, 2013

The French company has created a transgenic tadpole that fluoresces when it encounters chemical contaminants in water that disrupt thyroid functioning

Scientists on CSS's contract supporting the U.S. EPA's National Exposure Research Laboratory in Cincinnati, Ohio are helping the EPA evaluate a new technology created by a French biotechnology company as part of its Thyroid Biosensor Project.

The French company has created a transgenic tadpole that fluoresces when it encounters chemical contaminants in water that disrupt thyroid functioning. The test promises to provide an additional method for identifying a class of endocrine-disrupting pollutants, which are of increasing interest to pollution regulators.

Contract scientists work closely with EPA scientists and collaborators at the University of Cincinnati, assisting in the culturing of transgenic Xenopus laevis, rearing embryos to tadpoles, sorting tadpoles into transgenic/non-transgenic lines, and providing transgenic tadpoles to EPA scientists, who then conduct the exposure studies on these organisms.

This technology was recently featured in an article in "Scientific American", which can be found at http://www.scientificamerican.com/article.cfm?id=transgenic-tadpole-glows-to-reveal-chemical-contamination.